Variant in CAPN10 gene and environmental factors show evidence of association with excess weight among young people in a Colombian population
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Orozco Posada, Ana Carolina | 2014
Introduction: Obesity results from interaction between genetic and environmental risk factors.
Objective: To evaluate the effect of three gene variants and environmental factors on obesity and
overweight in young people aged 10 to 18 years in a Colombian population.
Materials and methods: A total of 424 subjects were selected and separated into three groups for a
cross-sectional study; 100 obese and 112 overweight subjects were matched with 212 normal-weight
controls. Associations were evaluated between excess weight and three genetic polymorphisms (UCP3-
rs1800849, FTO-rs17817449, and CAPN10-rs3842570), as well as the family history, the time spent
watching television and playing video games, and the diet.
Results: A family history of obesity, the time spent watching television and playing video games, the lack
of breastfeeding, a low consumption of cereals, legumes, fruits, vegetables, and a high consumption of
fast foods were characteristics typically found in obese individuals compared to controls. A significant
association between genotype I/I (SNP19 of CAPN10) and excess weight was found even with an active
lifestyle. In addition, significant associations between the C/C genotype of the UCP3 gene and the G/G
and T/T genotypes of the FTO gene and excess weight were found only in young sedentary individuals.
Conclusions: In this population, inadequate diet and sedentary lifestyle increased the risk of excess
weight. Genotype I/I of SNP19 in CAPN10 was significantly associated with excess weight. In contrast,
FTO and UCP3 variants exhibited effects only in sedentary environments.
Key words: Obesity, adolescent, risk factors, motor activity, Colombia
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